Table 1 General features of patients with dermatomyositis with versus without anti-Jo-1 autoantibodies
From: The relevance of anti-Jo-1 autoantibodies in patients with definite dermatomyositis
Anti-Jo-1 (+) (n = 10) | Anti-Jo-1 (−) (n = 108) | P value | |
|---|---|---|---|
Age at diagnosis (years) | 46.5 ± 16.4 | 43.9 ± 15.6 | 0.638 |
Sex: female | 5 (50.0) | 77 (71.3) | 0.171 |
Ethnicity: white | 9 (90.0) | 86 (79.6) | 0.684 |
Disease duration (years) | 5.0 [1.8–8.0] | 7.0 [4.0–12.0] | 0.093 |
Duration of follow-up (months) | 36.6 [18.8–95.6] | 56.0 [27.5–85.5] | 0.804 |
Constitutional symptoms (baseline) | 9 (90.0) | 77 (71.3) | 0.283 |
Cumulative manifestations | |||
Cutaneous involvement | |||
Gottron papules | 10 (100.0) | 108 (100.0) | > 0.999 |
Gottron sign | 10 (100.0) | 108 (100.0) | > 0.999 |
Heliotrope eruption | 10 (100.0) | 108 (100.0) | > 0.999 |
Facial erythema | 5 (50.0) | 88 (81.5) | 0.034 |
Raynaud phenomenon | 8 (80.0) | 62 (57.4) | 0.312 |
“V-neck” sign | 3 (30.0) | 71 (65.7) | 0.044 |
“Shawl” sign | 4 (40.0) | 54 (50.0) | 0.036 |
Vasculitis | 0 | 37 (34.3) | – |
Digital ulcers | 0 | 31 (28.7) | – |
Periungual erythema | 7 (70.0) | 84 (77.8) | 0.694 |
“Mechanic’s hands” | 7 (70.0) | 13 (12.0) | < 0.001 |
Calcinosis cutis | 0 | 7 (65.0) | – |
Joint involvement | 8 (80.0) | 34 (31.5) | 0.004 |
Lung involvement | 10 (100.0) | 33 (30.6) | < 0.001 |
Dyspnea | 8 (80.0) | 30 (28.7) | 0.002 |
Incipient interstitial lung disease | 10 (100.0) | 28 (25.9) | < 0.001 |
Pulmonary fibrosis | 1 (10.0) | 4 (3.7) | 0.363 |
Ground-glass opacities | 6 (60.0) | 7 (6.5) | < 0.001 |
Laboratory findings | |||
Antinuclear antibodies | 9 (90.0) | 81 (75.0) | > 0.999 |
Anti-Mi-2 | 0 | 12 (11.1) | – |
Anti-Ro-52 | 2 (20.0) | 22 (20.4) | > 0.999 |
Maximum creatine kinase levels (U/L) | 4522 [2173–13,500] | 2208 [253–8394] | 0.118 |
Maximum aldolase levels (U/L) | 50 [20.6–74.8] | 28.1 [9.0–90.5] | 0.617 |