From: Hematopoietic stem cell transplantation for systemic sclerosis: Brazilian experience
Transplant-related complicationsa | N (%) |
---|---|
Nausea/vomiting | 70 (100%) |
Alopecia | 70 (100%) |
Neutropenic fever | 65 (93%) |
Bacterial pneumonia | 5 (7%) |
Cyclophosphamide-induced cardiac dysfunction | 4 (6%) |
Sepsis | 2 (3%) |
Melphalan-induced mucositis | 2 (3%) |
Central catheter-related pneumothorax | 1 (1%) |
Acalculous cholecystitis | 1 (1%) |
Polyomavirus-induced hemorrhagic cystitis (mild) | 1 (1%) |
CMV reactivation (no CMV disease) | 10 (14%) |
Transplant-related deaths (total): | 3 (4%) |
Sepsis, Acinetobacter baumannii | |
Complications of acalculous cholecystitis Acute myocardial toxicity | |
Disease reactivations | |
Skin worsening | 3 (4%) |
Pulmonary function worsening | 6 (9%) |
Inflammatory myopathy | 2 (3%) |
Gastrointestinal progression/gastroparesis | 4 (6%) |
Other (SLE reactivation, cytopenia) requiring immunosuppression | 2 (3%) |
Disease-associated deaths (total): | 9 (13%) |
Acute lung exacerbation (3 patients) | |
Gastrointestinal progression (2 patients) | |
Cardiac insufficiency (2 patients) | |
Scleroderma renal crisis (1 patient) | |
Pulmonary embolism (1 patient) | |
Non-disease related events | |
Thrombotic thrombocytopenic purpura (death) | 1 (1%) |
Pregnancies in female transplanted patients | 3 (5.5%) |