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Table 2 Complications and disease-related events after transplantation

From: Hematopoietic stem cell transplantation for systemic sclerosis: Brazilian experience

Transplant-related complicationsa

N (%)

Nausea/vomiting

70 (100%)

Alopecia

70 (100%)

Neutropenic fever

65 (93%)

Bacterial pneumonia

5 (7%)

Cyclophosphamide-induced cardiac dysfunction

4 (6%)

Sepsis

2 (3%)

Melphalan-induced mucositis

2 (3%)

Central catheter-related pneumothorax

1 (1%)

Acalculous cholecystitis

1 (1%)

Polyomavirus-induced hemorrhagic cystitis (mild)

1 (1%)

CMV reactivation (no CMV disease)

10 (14%)

Transplant-related deaths (total):

3 (4%)

 Sepsis, Acinetobacter baumannii

 

 Complications of acalculous cholecystitis

 Acute myocardial toxicity

 

Disease reactivations

 Skin worsening

3 (4%)

 Pulmonary function worsening

6 (9%)

 Inflammatory myopathy

2 (3%)

 Gastrointestinal progression/gastroparesis

4 (6%)

 Other (SLE reactivation, cytopenia) requiring immunosuppression

2 (3%)

 Disease-associated deaths (total):

9 (13%)

 Acute lung exacerbation (3 patients)

 

 Gastrointestinal progression (2 patients)

 

 Cardiac insufficiency (2 patients)

 

 Scleroderma renal crisis (1 patient)

 

 Pulmonary embolism (1 patient)

 

Non-disease related events

 Thrombotic thrombocytopenic purpura (death)

1 (1%)

 Pregnancies in female transplanted patients

3 (5.5%)

  1. Number of complications associated or not associated with the transplant procedure, including disease reactivation and long-term survival outcomes
  2. CMV cytomegalovirus, SLE systemic lupus erythematosus (disease overlap)
  3. aComplications associated to the procedure within 60 days after HSCT