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Table 2 Complications and disease-related events after transplantation

From: Hematopoietic stem cell transplantation for systemic sclerosis: Brazilian experience

Transplant-related complicationsa N (%)
Nausea/vomiting 70 (100%)
Alopecia 70 (100%)
Neutropenic fever 65 (93%)
Bacterial pneumonia 5 (7%)
Cyclophosphamide-induced cardiac dysfunction 4 (6%)
Sepsis 2 (3%)
Melphalan-induced mucositis 2 (3%)
Central catheter-related pneumothorax 1 (1%)
Acalculous cholecystitis 1 (1%)
Polyomavirus-induced hemorrhagic cystitis (mild) 1 (1%)
CMV reactivation (no CMV disease) 10 (14%)
Transplant-related deaths (total): 3 (4%)
 Sepsis, Acinetobacter baumannii  
 Complications of acalculous cholecystitis
 Acute myocardial toxicity
 
Disease reactivations
 Skin worsening 3 (4%)
 Pulmonary function worsening 6 (9%)
 Inflammatory myopathy 2 (3%)
 Gastrointestinal progression/gastroparesis 4 (6%)
 Other (SLE reactivation, cytopenia) requiring immunosuppression 2 (3%)
 Disease-associated deaths (total): 9 (13%)
 Acute lung exacerbation (3 patients)  
 Gastrointestinal progression (2 patients)  
 Cardiac insufficiency (2 patients)  
 Scleroderma renal crisis (1 patient)  
 Pulmonary embolism (1 patient)  
Non-disease related events
 Thrombotic thrombocytopenic purpura (death) 1 (1%)
 Pregnancies in female transplanted patients 3 (5.5%)
  1. Number of complications associated or not associated with the transplant procedure, including disease reactivation and long-term survival outcomes
  2. CMV cytomegalovirus, SLE systemic lupus erythematosus (disease overlap)
  3. aComplications associated to the procedure within 60 days after HSCT