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Table 1 Baseline clinical and demographic characteristics in PP population

From: Treatment of knee osteoarthritis with a new formulation of a fixed-dose combination of glucosamine sulfate and bovine chondroitin: a multicenter, randomized, single-blind, non-inferiority clinical trial

Baseline characteristics GS/CS (N = 209) RP (N = 223)
Female, n (%) 184 (88) 193 (86.6)
Age, mean (sd), years 62.8 (8.9) 63 (8)
Caucasian, n (%) 133 (63.6) 133 (59.6)
Osteoarthritis duration, mean (sd), years 7.7 (6.9) 7.4 (5.7)
BMI, mean (sd), kg/m2 30.4 (4.7) 30.7 (4.4)
Kellgren-Lawrence grading, n (%)
II 146 (69.9) 151 (67.7)
III 63 (30.1) 72 (32.3)
Overall assessment of OA by the patient, mean (sd), VAS 0-100 mm 66.7 (18.1) 65 (19.2)
Overall assessment of OA by the physician, mean (sd), VAS 0-100 mm 61.8 (12.5) 62.9 (14.1)
WOMAC, mean (sd), mm
Pain subscale 66.3 (13.2) 68.1 (13.5)
Stiffness subscale 64.9 (21.1) 65.4 (20.9)
Physical function subscale 65.7 (13.7) 65.4 (14.6)
Total score 196.9 (39.9) 198.9 (41.7)
SF-12, mean (sd)   
Physical component 34.9 (7.4) 35.7 (7.5)
Mental component 49 (10.6) 46.9 (11.3)
Comorbidities (reported by ≥ 5% of patients), n (%)
Back pain 56 (25.8) 61 (27.4)
Musculoskeletal pain / Arthralgia / Pain in the extremities 46 (22) 46 (20.6)
Osteoporosis/ Osteopenia 34 (16.3) 30 (13.5)
Dyslipidemia / Hypercholesterolemia 69 (33) 70 (31.4)
Impaired glucose tolerance 33 (15.8) 40 (17.9)
Headache / Migraine 60 (28.7) 77 (34.5)
Hypothyroidism 40 (19.1) 39 (17.5)
Gastritis 26 (12.4) 30 (13.5)
Gastroesophageal reflux disease 9 (4.3) 14 (6.3)
Depression 13 (6.2) 17 (7.6)
Insomnia 11 (5.3) 15 (6.7)
Systemic arterial hypertension 128 (61.2) 130 (58.3)
Lower limbs varices 44 (21.1) 69 (30.9)
  1. P < 0,05 between groups for all characteristics. BMI body mass index, kg/m2 kilogram per square meter, GS/CS glucosamine sulfate/ chondroitin sulfate, n (%) number and percentage of patients in relation to the total number of patients in PP population, OA osteoarthritis, PP per protocol, RP reference product, sd standard deviation, SF-12 short-form 12 questionnaire, VAS visual analogue scale, WOMAC Western Ontario and McMaster Universities index