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Table 1 Characteristics of patients according to serological status

From: Abdominal symptoms during Sjogren’s syndrome: a pilot study

 

SSA+ (n = 80)

SSA- (n = 70)

TOTAL (n = 150)

p-value a

n (%)

Male

3 (3.7)

6 (8.7)

9 (6.0)

n.s.

Age at diagnosis, years

51.2 (13.4)

55.0 (11.0)

53.0 (12.5)

n.s.

Mean follow-up, years

10.3 (7.9)

9.6 (6.9)

10.0 (7.4)

n.s.

Salivary gland enlargement

21 (26.3)

19 (27.1)

40 (26.5)

n.s.

Raynaud’s phenomenon

29 (36,3)

18 (25.7)

47 (31.1)

n.s.

Articular involvement

56 (70.0)

51 (72.9)

107 (70.9)

n.s.

Muscular involvement

32 (40.0)

35 (50.0)

67 (44.4)

n.s.

Neurologic involvement

15 (18.8)

19 (27.1)

34 (22.5)

n.s.

Cutaneous vasculitis

9 (11.3)

1 (1.4)

10 (6.6)

0.026

Pulmonary involvement

11 (13.8)

5 (7.1)

16 (10.6)

n.s.

Interstitial nephritis

6 (7.5)

2 (2.9)

8 (5.3)

n.s.

Fibromyalgia

2 (2.5)

10 (7.0)

12 (8.0)

n.s.

Depression

12 (15.0)

20 (28.6)

32 (21.3)

0.0481

Hematological involvement

23 (28.8)

8 (11.4)

31 (20.5)

0.0090

Non-Hodgkin lymphoma

2 (2.5)

0

2 (1.3)

n.s.

Hypergammaglobulinemia

35 (43.8)

2 (2.9)

37 (24.5)

< 0.0001

Positive RF

12 (15.0)

2 (2.9)

14 (9.3)

0.0115

Cryoglobulinemia

4 (5.0)

1 (1.4)

5 (3.3)

n.s.

Symptomatic treatment of pSS

67 (83.7)

58 (84.0)

126 (84.0)

n.s.

Specific treatment of pSS

52 (65.0)

35 (50.7)

88 (58.7)

n.s.

Digestive treatment

33 (41.2)

39 (56.5)

73 (48.7)

n.s.

 

mean (sd)

 

ESSDAI score

3.5 (4.9)

3.2 (4.8)

3.4 (4.8)

n.s.

ESSPRI score

5.5 (2.1)

6.4 (1.9)

5.9 (2.1)

0.0082

  1. RF rheumatoid factor, pSS primary Sjögren’s syndrome, n.s not significant, sd standard deviation
  2. aFor qualitative variables, a Chi-2 or Fisher’s exact test was used to compare different groups of patients (SSA+ patients and seronegative patients). For quantitative variables in a normal distribution, the Student’s t-test was used to compare groups of two or more classes; for variables that do not follow a normal distribution, the Wilcoxon signed-rank test or the Kruskal-Wallis test was used to compare groups of two or more classes. The value p < 0.05 was considered significant