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Table 1 Characteristics of patients according to serological status

From: Abdominal symptoms during Sjogren’s syndrome: a pilot study

  SSA+ (n = 80) SSA- (n = 70) TOTAL (n = 150) p-value a
n (%)
Male 3 (3.7) 6 (8.7) 9 (6.0) n.s.
Age at diagnosis, years 51.2 (13.4) 55.0 (11.0) 53.0 (12.5) n.s.
Mean follow-up, years 10.3 (7.9) 9.6 (6.9) 10.0 (7.4) n.s.
Salivary gland enlargement 21 (26.3) 19 (27.1) 40 (26.5) n.s.
Raynaud’s phenomenon 29 (36,3) 18 (25.7) 47 (31.1) n.s.
Articular involvement 56 (70.0) 51 (72.9) 107 (70.9) n.s.
Muscular involvement 32 (40.0) 35 (50.0) 67 (44.4) n.s.
Neurologic involvement 15 (18.8) 19 (27.1) 34 (22.5) n.s.
Cutaneous vasculitis 9 (11.3) 1 (1.4) 10 (6.6) 0.026
Pulmonary involvement 11 (13.8) 5 (7.1) 16 (10.6) n.s.
Interstitial nephritis 6 (7.5) 2 (2.9) 8 (5.3) n.s.
Fibromyalgia 2 (2.5) 10 (7.0) 12 (8.0) n.s.
Depression 12 (15.0) 20 (28.6) 32 (21.3) 0.0481
Hematological involvement 23 (28.8) 8 (11.4) 31 (20.5) 0.0090
Non-Hodgkin lymphoma 2 (2.5) 0 2 (1.3) n.s.
Hypergammaglobulinemia 35 (43.8) 2 (2.9) 37 (24.5) < 0.0001
Positive RF 12 (15.0) 2 (2.9) 14 (9.3) 0.0115
Cryoglobulinemia 4 (5.0) 1 (1.4) 5 (3.3) n.s.
Symptomatic treatment of pSS 67 (83.7) 58 (84.0) 126 (84.0) n.s.
Specific treatment of pSS 52 (65.0) 35 (50.7) 88 (58.7) n.s.
Digestive treatment 33 (41.2) 39 (56.5) 73 (48.7) n.s.
  mean (sd)  
ESSDAI score 3.5 (4.9) 3.2 (4.8) 3.4 (4.8) n.s.
ESSPRI score 5.5 (2.1) 6.4 (1.9) 5.9 (2.1) 0.0082
  1. RF rheumatoid factor, pSS primary Sjögren’s syndrome, n.s not significant, sd standard deviation
  2. aFor qualitative variables, a Chi-2 or Fisher’s exact test was used to compare different groups of patients (SSA+ patients and seronegative patients). For quantitative variables in a normal distribution, the Student’s t-test was used to compare groups of two or more classes; for variables that do not follow a normal distribution, the Wilcoxon signed-rank test or the Kruskal-Wallis test was used to compare groups of two or more classes. The value p < 0.05 was considered significant