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Table 1 Mixed effects analysis of group effects (Fibromyalgia vs. Healthy Control) and time effects (Baseline, 3 Applications, 6 Applications, 3 Months) as well as interaction. A significant interaction effect indicates differences in value development/performance over time depending on the cohort

From: Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles

  Group Effect Time Effect Interaction
IL1 p <  0.0001 p <  0.0001 p <  0.0001
IL6 p = 0.0005 p = 0.0009 p = 0.0053
IL10 p = 0.0008 p = 0.0032 p <  0.0001
TNF-alpha p = 0.0096 p = 0.8783 p = 0.1271
VAS p <  0.0001
FIQ p <  0.0001