Fig. 2

Forest plot (random-effects model Mean Differences) of the unstimulated whole salivary flow rate in patients with Sjögren’s Syndrome compared to controls (healthy subjects and patients with sicca non-SS). This forest plot summarizes the results of studies evaluating the unstimulated whole salivary flow rate in patients with Sicca symptoms (SS vs controls). The numbers on the x-axis measure mean difference. The small green boxes represent the point estimate of the effect size and sample size of each study. The black lines on either side of the box represent a 95% confidence interval. The solid vertical line represents a mean difference of 0 or no effect. The overall pooled mean difference and 95% CI is indicated by a diamond at the bottom. Names of the first author’s studies are shown on the left. CI: Confidence Interval; df: degree freedom; Chi2: chi-squared test; I2: Higgins heterogeneity test; SD: Standard deviation; SS: Sjögren’s Syndrome