Table 3 Characteristics of patients who used methotrexate (MTX) and presented adverse drug reactions (ADRs)
Variable | ADRs of MTX (N = 398) | ||
|---|---|---|---|
Yes | No | ρ* | |
n = 252 | n = 146 | ||
Sex (%) | |||
Female | 174 (63.3) | 101 (36.7) | 0.978 |
Male | 78 (63.4) | 45 (36.6) | |
Age (years) – Cohort in median | |||
≤ 16 | 236 (72.6) | 89 (27.4) | < 0.001 |
> 16 | 16 (21.9) | 57 (78.1) | |
Route of administration of MTX (%) | |||
Subcutaneous | 40 (62.5) | 24 (37.5) | 0.882 |
Oral | 212 (63.5) | 122 (36.5) | |
Dose of MTX (mg/kg/week) | |||
≥ 0.6 | 175 (69.7) | 76 (30.3) | 0.001 |
< 0.6 | 77 (52.4) | 70 (47.6) | |
Disease (%) | |||
JIA | 207 (68.1) | 97 (31.9) | 0.001 |
JSLE | 20 (57.1) | 15 (42.9) | |
JDM | 25 (42.4) | 34 (57.6) | |