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Table 1 Overall Test Characteristics of Anti-Rib Proteins by ELISA in ROC Curve Analysis

From: The diagnostic benefit of antibodies against ribosomal proteins in systemic lupus erythematosus

 

Anti-Rib-PELISA a

Anti-Rib-P0

Anti-Rib-P1

Anti-Rib-P2

Area under the curve (AUC) with 95% confidence interval (CI)

0.778 (0.683–0.872)

0.724 (0.625–0.822)

0.677(0.576–0.778)

0 .686 (0.587–0.785)

Maximal sum of sensitivity and specificityc

153% (22.10)

145% (1.04)

143% (0.67)

146% (0.421)

Sensitivity at 95% specificity cut-off b

36.6% (17.69)

47.6% (0.98)

47.6% (0.70)

46.3% (0.49)

Sensitivity at 99% specificity cut-off b

35.4% (23.8)

45.1% (1.04)

32.9% (0.92)

40.2% (0.597)

  1. aAnti-Rib-PELISA means antibodies directly against native ribosomal P heterocomplex determined by ELISA
  2. bCut-off values are presented in relative units/ml for anti-Rib-PELISA, and in optical densities (OD450) for anti-Rib-P0, anti-Rib-P1, and anti-Rib-P2 antibodies
  3. c Numbers in the parentheses refer to the relative-units or OD value to achieve the Maximal sum of sensitivity and specificity
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Advances in Rheumatology

ISSN: 2523-3106