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Table 1 Overall Test Characteristics of Anti-Rib Proteins by ELISA in ROC Curve Analysis

From: The diagnostic benefit of antibodies against ribosomal proteins in systemic lupus erythematosus

  Anti-Rib-PELISA a Anti-Rib-P0 Anti-Rib-P1 Anti-Rib-P2
Area under the curve (AUC) with 95% confidence interval (CI) 0.778 (0.683–0.872) 0.724 (0.625–0.822) 0.677(0.576–0.778) 0 .686 (0.587–0.785)
Maximal sum of sensitivity and specificityc 153% (22.10) 145% (1.04) 143% (0.67) 146% (0.421)
Sensitivity at 95% specificity cut-off b 36.6% (17.69) 47.6% (0.98) 47.6% (0.70) 46.3% (0.49)
Sensitivity at 99% specificity cut-off b 35.4% (23.8) 45.1% (1.04) 32.9% (0.92) 40.2% (0.597)
  1. aAnti-Rib-PELISA means antibodies directly against native ribosomal P heterocomplex determined by ELISA
  2. bCut-off values are presented in relative units/ml for anti-Rib-PELISA, and in optical densities (OD450) for anti-Rib-P0, anti-Rib-P1, and anti-Rib-P2 antibodies
  3. c Numbers in the parentheses refer to the relative-units or OD value to achieve the Maximal sum of sensitivity and specificity