Table 4 Quality of evidence of the reviews included according to GRADE
Impact | Confidence | Importance | |||||||
|---|---|---|---|---|---|---|---|---|---|
No. studies | Study design | Risk of Bias | Inconsistency | Indirect evidence | Imprecision | Other considerations | |||
Pain | |||||||||
8 | SR of CT | Not serious | Serious a | Not serious | Not serious | Highly suspicious | Favors AMT | ++ Low | Critical |
Sleep | |||||||||
6 | SR of CT | Not serious | Serious a | Not serious | Not serious | None | Favors AMT | +++ Moderate | Critical |
Fatigue | |||||||||
7 | SR of CT | Not serious | Not serious | Not serious | Not serious | Highly-suspicious publication bias | Favors AMT | +++ Moderate | Critical |
Mood Disorder | |||||||||
4 | SR of CT | Not serious | Not serious | Not serious | Not serious | None | Favors DLX | ++++ High | Critical |
Quality of life | |||||||||
5 | SR of CT | Not serious | Not serious | Not serious | Not serious | None | Favors AMT | ++++ High | Critical |
Safety and acceptability | |||||||||
7 | SR of CT | Not serious | Serious b | Not serious | Not serious | Highly suspicious publication bias | DLX with higher acceptability and safety for elderlies; AMT with higher safety for non-elderlies | ++ Low | Critical |