|
Pre-rTMS
|
Post-rTMS
|
Follow-up
|
---|
FU-1 (15-days)
|
FU-2 (3-months)
|
FU-3 (6-months)
|
---|
MPQ: Sensory
|
Sham
|
23.0 (17.0–26.5)
|
20.0 (17.0–24.5)
|
22.0 (20.0–23.0)
|
22.0 (21.0–23.0)
|
22.0 (20.0–24.0)
|
Real
|
23.0 (21.0–26.0)
|
23.0 (18.3–26.8)
|
21.0 (18.0–26.0)
|
22.0 (18.0–25.5)
|
22.0 (18.0–28.0)
|
p*
|
0.40
|
0.29
|
0.89
|
0.72
|
0.74
|
MPQ: Affective-motivational
|
Sham
|
8.0 (4.5–9.0)
|
7.0 (4.0–8.0)
|
6.0 (4.0–8.0)
|
6.0 (4.0–8.0)
|
6.0 (5.0–7.5)
|
Real
|
7.0 (5.0–8.0)
|
3.0 (3.0–4.0)##
|
4.0 (3.0–4.5)
|
4.0 (3.0–5.0)
|
4.0 (3.0–5.0)
|
p*
|
0.10
|
0.001
|
0.001
|
0.001
|
0.001
|
MPQ: Evaluative
|
Sham
|
3.0 (3.0–3.5)
|
3.0 (2.0–3.5)
|
3.0 (2.0–3.5)
|
2.0 (1.0–3.5)
|
3.0 (2.0–4.0)
|
Real
|
3.0 (3.0–4.0)
|
2.0 (1.0–2.0)##
|
2.0 (1.0–2.0)
|
2.0 (1.0–2.0)
|
2.0 (1.0–2.0)
|
p*
|
0.33
|
0.001
|
0.001
|
0.004
|
0.001
|
MPQ: Miscellaneous
|
Sham
|
9.0 (4.25–10.75)
|
7.0 (5.0–8.0)
|
7.0 (4.0–9.0)
|
7.0 (5.0–9.0)
|
7.0 (5.0–9.0)
|
Real
|
7.0 (4.0–9.0)
|
6.0 (4.0–9.0)
|
5.0 (3.0–9.0)
|
6.0 (3.5–9.0)
|
7.0 (4.0–10.0)
|
p*
|
0.34
|
0.33
|
0.51
|
0.45
|
0.95
|
MPQ: Total score
|
Sham
|
39.0 (36.0–44.0)
|
39.0 (33.0–45.0)
|
38.0 (34.0–41.5)
|
39.0 (34.5–41.0)
|
38.0 (32.5–41.0)
|
Real
|
39.0 (36.0–44.5)
|
20.0 (16.0–29.5) ##
|
20.0 (17.0–30.0)
|
20.0 (17.0–30.0)
|
21.0 (18.0–29.0)
|
p*
|
0.87
|
0.001
|
0.001
|
0.001
|
0.001
|
MPQ: Present pain intensity
|
Sham
|
3.0 (2.0–3.0)
|
2.0 (1.0–2.0)
|
2.0 (2.0–3.0)
|
2.0 (2.0–3.0)
|
2.0 (2.0–3.0)
|
Real
|
3.0 (2.0–4.0)
|
1.0 (1.0–2.0)##
|
2.0 (1.0–2.0)
|
2.0 (1.0–2.0)
|
2.0 (1.0–2.0)
|
p*
|
0.60
|
0.001
|
0.001
|
0.001
|
0.001
|
WHOQOL-BREF: Physical
|
Sham
|
38.0 (38.0–44.0)
|
43.0 (38.0–50.0)
|
44.0 (38.0–47.0)
|
44.0 (38.0–50.0)
|
44.0 (38.0–47.0)
|
Real
|
38.0 (31.0–50.0)
|
44.0 (38.0–56.0) #
|
47.0 (40.0–62.0)
|
44.0 (40.0–56.0)
|
44.0 (38.0–56.0)
|
p*
|
0.59
|
0.05
|
0.05
|
0.05
|
0.05
|
WHOQOL-BREF: Psychological
|
Sham
|
56.0 (38.0–69)
|
59.0 (38.0–75.0)
|
44.0 (44.0–69.0)
|
56.0 (38.0–69.0)
|
56.0 (44.0–75.0)
|
Real
|
56.0 (44.0–56.0)
|
69.0 (56.0–75.0) #
|
69.0 (56.0–75.0)
|
58.0 (56.0–69.0)
|
69.0 (56.0–69.0)
|
p*
|
0.74
|
0.002
|
0.004
|
0.04
|
0.05
|
WHOQOL-BREF: Social
|
Sham
|
44.0 (44.0–56.0)
|
50.0 (44.0–56.0)
|
44.0 (44.0–56.0)
|
44.0 (43.0–56.0)
|
50.0 (44.0–56.0)
|
Real
|
50.0 (31.0–69.0)
|
56.0 (44.0–69.0) #
|
56.0 (53.0–69.0)
|
56.0 (47.0–69.0)
|
56.0 (50.0–69.0)
|
p*
|
0.57
|
0.004
|
0.001
|
0.001
|
0.02
|
WHOQOL-BREF: Environmental
|
Sham
|
56.0 (44.0–69)
|
56.0 (47.0–69.0)
|
56.0 (44.0–72.0)
|
56.0 (44.0–69.0)
|
56.0 (44.0–69.0)
|
Real
|
69.0 (56.0–69.0)
|
56.0 (53.0–75.0)
|
56.0 (53.0–69.0)
|
49.0 (56.0–72.0)
|
56.0 (48.5–69.0)
|
p*
|
0.06
|
0.28
|
0.91
|
0.28
|
0.94
|
- Sham (n = 41) and Real (n = 45); Data is presented as Median (25Q-75Q); MPQ: McGill Pain Questionnaire; WHOQOL-BREF: WHO-Quality of Life questionnaire.; Asterisk (*) symbol indicates p value between Sham-rTMS and Real-rTMS group. Hash (#) symbol indicates p value within group. *p or #p < 0.05; **p or ##p < 0.01; ***p or ###p < 0.001.