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Table 2 Comparison of subjective pain measures in FMS Sham-rTMS and Real-rTMS group

From: Repetitive transcranial magnetic stimulation of the prefrontal cortex for fibromyalgia syndrome: a randomised controlled trial with 6-months follow up

  Pre-rTMS Post-rTMS Follow-up
FU-1 (15-days) FU-2 (3-months) FU-3 (6-months)
MPQ: Sensory
Sham 23.0 (17.0–26.5) 20.0 (17.0–24.5) 22.0 (20.0–23.0) 22.0 (21.0–23.0) 22.0 (20.0–24.0)
Real 23.0 (21.0–26.0) 23.0 (18.3–26.8) 21.0 (18.0–26.0) 22.0 (18.0–25.5) 22.0 (18.0–28.0)
p* 0.40 0.29 0.89 0.72 0.74
MPQ: Affective-motivational
 Sham 8.0 (4.5–9.0) 7.0 (4.0–8.0) 6.0 (4.0–8.0) 6.0 (4.0–8.0) 6.0 (5.0–7.5)
 Real 7.0 (5.0–8.0) 3.0 (3.0–4.0)## 4.0 (3.0–4.5) 4.0 (3.0–5.0) 4.0 (3.0–5.0)
 p* 0.10 0.001 0.001 0.001 0.001
MPQ: Evaluative
 Sham 3.0 (3.0–3.5) 3.0 (2.0–3.5) 3.0 (2.0–3.5) 2.0 (1.0–3.5) 3.0 (2.0–4.0)
 Real 3.0 (3.0–4.0) 2.0 (1.0–2.0)## 2.0 (1.0–2.0) 2.0 (1.0–2.0) 2.0 (1.0–2.0)
 p* 0.33 0.001 0.001 0.004 0.001
MPQ: Miscellaneous
 Sham 9.0 (4.25–10.75) 7.0 (5.0–8.0) 7.0 (4.0–9.0) 7.0 (5.0–9.0) 7.0 (5.0–9.0)
 Real 7.0 (4.0–9.0) 6.0 (4.0–9.0) 5.0 (3.0–9.0) 6.0 (3.5–9.0) 7.0 (4.0–10.0)
 p* 0.34 0.33 0.51 0.45 0.95
MPQ: Total score
 Sham 39.0 (36.0–44.0) 39.0 (33.0–45.0) 38.0 (34.0–41.5) 39.0 (34.5–41.0) 38.0 (32.5–41.0)
 Real 39.0 (36.0–44.5) 20.0 (16.0–29.5) ## 20.0 (17.0–30.0) 20.0 (17.0–30.0) 21.0 (18.0–29.0)
 p* 0.87 0.001 0.001 0.001 0.001
MPQ: Present pain intensity
 Sham 3.0 (2.0–3.0) 2.0 (1.0–2.0) 2.0 (2.0–3.0) 2.0 (2.0–3.0) 2.0 (2.0–3.0)
 Real 3.0 (2.0–4.0) 1.0 (1.0–2.0)## 2.0 (1.0–2.0) 2.0 (1.0–2.0) 2.0 (1.0–2.0)
 p* 0.60 0.001 0.001 0.001 0.001
WHOQOL-BREF: Physical
 Sham 38.0 (38.0–44.0) 43.0 (38.0–50.0) 44.0 (38.0–47.0) 44.0 (38.0–50.0) 44.0 (38.0–47.0)
 Real 38.0 (31.0–50.0) 44.0 (38.0–56.0) # 47.0 (40.0–62.0) 44.0 (40.0–56.0) 44.0 (38.0–56.0)
 p* 0.59 0.05 0.05 0.05 0.05
WHOQOL-BREF: Psychological
 Sham 56.0 (38.0–69) 59.0 (38.0–75.0) 44.0 (44.0–69.0) 56.0 (38.0–69.0) 56.0 (44.0–75.0)
 Real 56.0 (44.0–56.0) 69.0 (56.0–75.0) # 69.0 (56.0–75.0) 58.0 (56.0–69.0) 69.0 (56.0–69.0)
 p* 0.74 0.002 0.004 0.04 0.05
WHOQOL-BREF: Social
 Sham 44.0 (44.0–56.0) 50.0 (44.0–56.0) 44.0 (44.0–56.0) 44.0 (43.0–56.0) 50.0 (44.0–56.0)
 Real 50.0 (31.0–69.0) 56.0 (44.0–69.0) # 56.0 (53.0–69.0) 56.0 (47.0–69.0) 56.0 (50.0–69.0)
 p* 0.57 0.004 0.001 0.001 0.02
WHOQOL-BREF: Environmental
 Sham 56.0 (44.0–69) 56.0 (47.0–69.0) 56.0 (44.0–72.0) 56.0 (44.0–69.0) 56.0 (44.0–69.0)
 Real 69.0 (56.0–69.0) 56.0 (53.0–75.0) 56.0 (53.0–69.0) 49.0 (56.0–72.0) 56.0 (48.5–69.0)
 p* 0.06 0.28 0.91 0.28 0.94
  1. Sham (n = 41) and Real (n = 45); Data is presented as Median (25Q-75Q); MPQ: McGill Pain Questionnaire; WHOQOL-BREF: WHO-Quality of Life questionnaire.; Asterisk (*) symbol indicates p value between Sham-rTMS and Real-rTMS group. Hash (#) symbol indicates p value within group. *p or #p < 0.05; **p or ##p < 0.01; ***p or ###p < 0.001.
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Advances in Rheumatology

ISSN: 2523-3106