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Table 1 Pharmacokinetic properties of chloroquine and hydroxychloroquine

From: Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases

  Chloroquine Hydroxychloroquine
Oral absorption Upper gastrointestinal tract Upper gastrointestinal tract
Distribution volume Blood 65,000 L
Plasma 15,000 L
Blood 47,257 L
Plasma 5500 L
Hepatic metabolism Desethylchloroquine 39% Desethylchloroquine 18%
Desethyl-hydroxychloroquine 16%
Renal clearance 51% 21%
Unmetabolized excretion 58% 62%
Terminal half-life 41 ± 11 days 45 ± 15 days
  1. Adapted from: Schrezenmeier E et al. [13]