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Table 4 Rheumatic manifestations in A143T and R118C subjects

From: Higher rate of rheumatic manifestations and delay in diagnosis in Brazilian Fabry disease patients

Signs/Symptoms/Diagnosis

Total

N (%)

Males

N (%)

Females

N (%)

p-value

A143T

N (%)

R118C

N (%)

p-value

Pain in the extremities (nociceptive and/or neuropathic)

10 (52.6%)

4 (50%)

6 (54.5%)

0.86

2 (50%)

8 (53.3%)

0.34

Fabry-like crises (past/present)

4 (21.1%)

0

4 (36.4%)

0.06

3 (75%)

1 (6.7%)

0.001

Osteopenia/osteoporosis/ low bone mineral density for age

11 (57.9%)

5 (62.5%)

6 (54.5%)

0.75

3 (75%)

8 (53.3%)

0.46

Fibromyalgia

7 (36.8%)

1 (12.5%)

6 (54.5%)

0.07

3 (75%)

4 (26.7%)

0.08

Chronic low back pain

3 (15.8%)

1 (12.5%)

2 (18.2%)

0.38

2 (50%)

1 (6.7%)

0.04

Hip/knee osteoarthritis

3 (15.8%)

2 (25%)

1 (9.1%)

0.38

0

3 (20%)

0.36

Trigger finger

1 (5.3%)

1 (12.5%)

0

0

1 (6.7%)

Cramps

1 (5.3%)

1 (12.5%)

0

0

1 (6.7%)

  1. Data in bold means that the difference of frequencies between males and females was statistically significant