Table 1 General features of patients with dermatomyositis and antisynthetase syndrome at disease onset
From: The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis
DM (n = 13) | ASS (n = 9) | P | |
|---|---|---|---|
Age at disease diagnosis (years) | 40.2 ± 11.5 | 40.2 ± 10.2 | 0.999 |
Clinical manifestations (%) | |||
Constitutional symptoms | 8 (61.5) | 8 (88.9) | 0.333 |
Skin involvement | |||
Heliotrope rash | 12 (92.3) | 0 | – |
Gottron’s sign | 12 (92.3) | 0 | – |
Gottron’s papule | 12 (92.3) | 0 | – |
“Mechanic’s hands” | 0 | 6 (66.7) | – |
Joint involvement | 2 (15.4) | 8 (88.9) | 0.001 |
Pulmonary involvement | 4 (30.8) | 9 (100.0) | 0.001 |
Raynaud’s phenomenon | 6 (46.2) | 8 (88.9) | 0.165 |
Dysphagia | 8 (61.5) | 3 (33.3) | 0.193 |
Muscle involvement (%) | |||
Upper limbs (muscle strength) | |||
Degree II | 0 | 0 | 0.689 |
Degree II | 0 | 0 | |
Degree III | 2 (15.8) | 2 (22.2) | |
Degree IV | 11 (84.2) | 6 (66.7) | |
Degree V | 0 | 1 (11.1) | |
Lower limbs (muscle strength) | |||
Degree II | 0 | 0 | 0.973 |
Degree II | 0 | 0 | |
Degree III | 3 (23.1) | 2 (22.2) | |
Degree IV | 9 (69.2) | 6 (66.7) | |
Degree V | 1 (7.7) | 1 (11.1) | |
Laboratory parameters | |||
Creatine phosphokinase (U/L) | 2300 (999–6326) | 967 (292–6654) | 0.366 |
Antisynthetase autoantibodies (%) | |||
Anti- Jo-1 | 0 | 8 (88.9) | – |
Anti-PL-12 | 0 | 1 (11.1) | – |