Table 2 Comparative analysis of main characteristics and treatment response in Systemic Lupus Erythematosus (SLE) patients with early and late onset nephritis
Early onset N = 50 | Late onset N = 21 | P | |
|---|---|---|---|
Glomerulonephritis classification | |||
Class II | 5 (10%) | 3 (14.2%) | 0.79 |
Class III | 10 (20%) | 3 (14.2%) | |
Class III+ V | 2 (4%) | 0 | |
Class IV | 25 (50%) | 13 (61.9%) | |
Class IV+ V | 1 (2%) | 0 | |
Class V | 7 (14%) | 2 (9.5%) | |
Induction treatment | |||
Cyclophosphamide | 44 (88%) | 20 (95.2%) | 0.66 |
MMF | 6 (12%) | 1 (4.7%) | |
Maintenance treatment | |||
Azathioprine | 31 (62%) | 14 (66.6%) | 1.00 |
MMF | 18 (36%) | 7 (33. 3%) | |
Treatment response in 2 years | |||
Total remission | 30 (60%) | 12 (57.1%) | 0.35 |
Partial remission | 10 (20%) | 2 (9.5%) | |
Treatment failure | 10 (20%) | 7 (33. 3%) | |
Median creatinine (IQR)- mg/dL | |||
Initial | 0.98 (0. 6-1. 3) | 0.97 (0. 7-1. 3) | 0.94 |
After 2 years | 0.80 (0. 7-1.1) | 0.74 (0. 6-1.0) | 0.45 |
Creatinine clearence (mL/min) | |||
Initial (median;IQR) | 83.5 (52. 3–120.6) | 82. 3 (52. 7-89.0) | 0.60 |
After 2 years (mean ± SD) | 94.7 ± 38.7 | 97.0 ± 37.8 | 0.81 |
Positive anti-ds-DNA | |||
Initial | 20 (40%) | 13 (61.9%) | 0.09 |
After 2 years | 14 (28%) | 9 (42.8%) | 0.22 |
Median 24 h proteinuria (g/L) (IQR) | |||
Initial | 2.9 (1. 7-5. 4) | 2.0 (1. 2-5.1) | 0.17 |
After 2 years | 0.36 (0. 1-1.1) | 0.35 (0. 1-1.0) | 0.48 |
C3 (mg/dL) | |||
Initial (median; IQR) | 72.5 (46. 5-99.6) | 85.7 (56. 4–104.5) | 0.22 |
After 2 years (mean ± SD) | 109. 4±29. 4 | 103. 3±36. 3 | 0.45 |
Median C4 (IQR) (mg/dL) | |||
Initial | 11.9 (7. 9-21.8) | 12.0 (7.0–23.2) | 0.93 |
After 2 years | 19.0 (13. 9-26.9) | 23.0 (13. 7-28.5) | 0.68 |
Hemoglobine (g/dL) | |||
Initial (mean ± SD) | 11.6 ± 2.2 | 12.8 ± 1.5 | 0.02 |
After 2 years (median;IQR) | 13.0 (12.0–14.1) | 12.6 (12.0–13.8) | 0.58 |
SLEDAI | |||
Initial (mean ± SD) | 14.8 ± 5. 4 | 13.2 ± 6.1 | 0.28 |
After 2 years (mean ± SD) | 5.8± 4.6 | 6. 4± 4.8 | 0.59 |
Median SLICC/ACR DI (IQR) | |||
Initial | 0 (0–1) | 0 (0–1) | 0.93 |
After 2 years | 0 (0–2) | 1.0 (0–2) | 0.41 |
Interval (years) until first recurrence – median (IQR) | 4.5 (2. 2-6.7) | 3.0 (1.0–5.0) | 0.07 |