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Table 6 Main diagnostic tests for the assessment of patients with primary Sjögren’s syndrome

From: Recommendations from the Brazilian society of rheumatology for the diagnosis of Sjögren’s syndrome (Part I): glandular manifestations (systematic review)

 DiagnosisOrgan involvementDisease activityaDrug toxicityAssociated autoimmune diseasesComorbidities
Complete blood count XXXX 
Urea, creatinine, sodium, and potassium levels
Venous blood gas level
24-h urine protein or urine protein/creatinine levels
Blood sugar levels
Levels of total cholesterol and its fractions and triglycerides
   X X
Levels of transaminases and canalicular enzymes   XX 
Creatine phosphokinase levels XX   
Protein electrophoresis XX X 
Chest radiograph High-resolution computed tomography of the lungs XX   
Electroneuromyography XX   
Magnetic resonance imaging of the head XX   
Anti-Ro/SSA and anti-La/SSB antibodiesX     
C3/C4 levels XX   
Levels of free T4, TSH, anti-thyroid peroxidase, anti- thyroglobulin,nti-mitochondrial, anti-smooth muscle, anti-gastric parietal cell antibodies    X 
Saliva flow rateX     
Salivary gland scintigraphyX     
Salivary gland ultrasoundX     
Minor salivary gland biopsyX     
  1. aDisease activity according to the EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI). Anti-dsDNA, anti-RNP, anti-Sm and anti-Scl-70 antibodies are useful for a differential diagnosis compared with other systemic autoimmune rheumatic diseases