Recommendations from the Brazilian society of rheumatology for the diagnosis of Sjögren’s syndrome (Part I): glandular manifestations (systematic review)

Table 6 Main diagnostic tests for the assessment of patients with primary Sjögren’s syndrome

	Diagnosis	Organ involvement	Disease activity^a	Drug toxicity	Associated autoimmune diseases	Comorbidities
Complete blood count		X	X	X	X
Urea, creatinine, sodium, and potassium levels Venous blood gas level Urinalysis 24-h urine protein or urine protein/creatinine levels		X	X	X		X
Blood sugar levels Levels of total cholesterol and its fractions and triglycerides				X		X
Levels of transaminases and canalicular enzymes				X	X
Creatine phosphokinase levels		X	X
Protein electrophoresis		X	X		X
Chest radiograph High-resolution computed tomography of the lungs		X	X
Electroneuromyography		X	X
Magnetic resonance imaging of the head		X	X
Anti-Ro/SSA and anti-La/SSB antibodies	X
C3/C4 levels		X	X
Levels of free T4, TSH, anti-thyroid peroxidase, anti- thyroglobulin,nti-mitochondrial, anti-smooth muscle, anti-gastric parietal cell antibodies					X
Saliva flow rate	X
Salivary gland scintigraphy	X
Salivary gland ultrasound	X
Minor salivary gland biopsy	X

^aDisease activity according to the EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI). Anti-dsDNA, anti-RNP, anti-Sm and anti-Scl-70 antibodies are useful for a differential diagnosis compared with other systemic autoimmune rheumatic diseases

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