Table 1 Baseline characteristics and reproductive history
Characteristic | Colombia (N = 277) | Brazil (N = 130) | Mexico (N = 83) | Argentina (N = 56) | All Patients Latin America Subregion (N = 546) |
|---|---|---|---|---|---|
Age (years), mean (SD) | 72.7 (9.8) | 68.6 (10.0) | 67.8 (11.0) | 72.4 (8.4) | 71.0 (10.1) |
Body mass index (kg/m2), mean (SD) | 25.1 (3.7) | 24.8 (4.5) | 25.6 (3.4) | 25.3 (4.0) | 25.2 (3.9) |
Bone mineral density (T-score), mean (SD) | |||||
Lumbar spine | −3.10 (1.11) (n = 185) | − 3.30 (1.21) (n = 105) | −2.46 (1.28) (n = 73) | −2.93 (1.40) (n = 50) | −3.02 (1.23) (n = 413) |
Total hip | −2.45 (1.05) (n = 50) | −1.80 (0.86) (n = 64) | −2.40 (0.68) (n = 58) | − 2.36 (1.23) (n = 27) | −2.21 (0.96) (n = 199) |
Femoral neck | −2.40 (0.95) (n = 137) | −1.96 (0.96) (n = 74) | −2.35 (0.86) (n = 28) | − 2.58 (0.90) (n = 39) | −2.31 (0.96) (n = 278) |
Patients older than 40 years with ≥1 previous low trauma fracture, n (%) | 187 (67.5%) | 67 (51.5%) | 46 (55.4%) | 43 (76.8%) | 343 (62.8%) |
Patients older than 40 years with previous low trauma fracture (by number of fractures), n (%) | |||||
No fractures | 90 (32.6%) | 63 (48.8%) | 37 (45.1%) | 13 (23.2%) | 203 (37.4%) |
1 fracture | 105 (38.0%) | 39 (30.2%) | 36 (43.9%) | 13 (23.2%) | 193 (35.5%) |
2 fractures | 55 (19.9%) | 15 (11.6%) | 8 (9.8%) | 13 (23.2%) | 91 (16.8%) |
3 fractures | 13 (4.7%) | 9 (7.0%) | 1 (1.2%) | 9 (16.1%) | 32 (5.9%) |
4 fractures | 7 (2.5%) | 1 (0.8%) | 0 (0.0%) | 1 (1.8%) | 9 (1.7%) |
5 or more fractures | 6 (2.2%) | 2 (1.6%) | 0 (0.0%) | 7 (12.5%) | 15 (2.8%) |
Previous fracture sites, n (%) | |||||
Vertebral | 96 (34.7%) | 28 (21.5%) | 7 (8.4%) | 35 (62.5%) | 166 (30.4%) |
Non-vertebral | 90 (32.5%) | 28 (21.5%) | 38 (45.8%) | 20 (35.7%) | 176 (32.2%) |
Main non-vertebrala | 70 (25.3%) | 18 (13.8%) | 26 (31.3%) | 14 (25.0%) | 128 (23.4%) |
Hip | 23 (8.3%) | 8 (6.2%) | 1 (1.2%) | 4 (7.1%) | 36 (6.6%) |
Reproductive history | |||||
Age at onset of menopause (years), mean (SD) | 48.7 (5.2) | 45.9 (6.6) | 46.6 (4.9) | 47.2 (5.0) | 47.5 (5.6) |
Number of fertile yearsb, median (Q1, Q3), years | 36.0 (32, 38) | 33.5 (28, 37) | 36.0 (33, 38) | 35.0 (32, 39) | 35.0 (31, 38) |
Parityc, n (%) patients | |||||
0 | 44 (15.9%) | 15 (11.5%) | 7 (8.4%) | 11 (19.6%) | 77 (14.1%) |
1 | 29 (10.5%) | 7 (5.4%) | 8 (9.6%) | 10 (17.9%) | 54 (9.9%) |
2 | 45 (16.3%) | 31 (23.8%) | 20 (24.1%) | 17 (30.4%) | 113 (20.7%) |
3 | 56 (20.3%) | 23 (17.7%) | 23 (27.7%) | 11 (19.6%) | 113 (20.7%) |
4 | 34 (12.3%) | 18 (13.8%) | 9 (10.8%) | 5 (8.9%) | 66 (12.1%) |
5 or more | 68 (24.6%) | 36 (27.7%) | 16 (19.3%) | 2 (3.6%) | 122 (22.4%) |
Early menopause (< age 40), n (%) | 12 (4.3%) | 18 (13.8%) | 5 (6.0%) | 5 (8.9%) | 40 (7.3%) |
Surgical menopause, n (%) | 46 (17.8%) | 17 (13.5%) | 35 (42.2%) | 8 (14.5%) | 106 (20.3%) |