Table 5 SLE clinical manifestations according to total C4, C4A and C4B gene copy number (GCN)
Clinical features | Â | Total C4 GCN n (%) | C4A GCN n (%) | C4B GCN n (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|  |  | < 4 n = 125 | ≥4 n = 302 | p-value | < 2 n = 87 | ≥2 n = 340 | p-value | < 2 n = 116 | ≥2 n = 311 | p-value |
Cutaneous | + | 116 (92.8) | 278 (92.0) | 1.000 | 82 (94.2) | 312 (91.7) | 0.509 | 106 (91.3) | 288 (92.6) | 0.686 |
– | 9 (7.2) | 24 (8.0) | 5 (5.8) | 28 (8.2) | 10 (8.7) | 23 (7.4) | ||||
Articular | + | 104 (83.2) | 269 (89.0) | 0.110 | 76 (87.3) | 297 (87.3) | 1.000 | 94 (81.0) | 279 (89.7) | 0.022 |
– | 21 (16.8) | 33 (11.0) | 11 (12.7) | 43 (12.7) | 22 (19.0) | 32 (10.3) | ||||
Hematologic | + | 90 (72.0) | 204 (67.5) | 0.422 | 65 (74.7) | 229 (67.3) | 0.197 | 82 (70.6) | 212 (68.1) | 0.640 |
– | 35 (28.0) | 98 (32.4) | 22 (25.3) | 111 (42.7) | 34 (29.4) | 99 (31.9) | ||||
Renal | + | 72 (57.6) | 174 (57.6) | 1.000 | 53 (60.9) | 193 (56.7) | 0.544 | 63 (54.3) | 183 (58.8) | 0.441 |
– | 53 (42.4) | 128 (42.4) | 34 (39.1) | 147 (43.3) | 53 (45.7) | 128 (41.2) | ||||
Serositis | + | 26 (20.8) | 85 (28.1) | 0.145 | 14 (16.0) | 97 (28.5) | 0.019 | 30 (25.8) | 81 (26.0) | 1.000 |
– | 99 (79.2) | 217 (71.9) | 73 (84.0) | 243 (71.5) | 86 (74.2) | 230 (74.0) | ||||
Neurologic | + | 34 (27.2) | 61 (20.1) | 0.125 | 14 (16.0) | 81 (23.8) | 0.148 | 33 (28.4) | 62 (19.9) | 0.067 |
– | 91 (72.8) | 241 (79.9) | 73 (84) | 259 (76.2) | 83 (71.6) | 249 (80.1) | ||||
Infection | + | 22 (17.6) | 38 (12.5) | 0.220 | 15 (17.2) | 45 (13.2) | 0.387 | 19 (16.3) | 41 (13.1) | 0.434 |
– | 103 (82.4) | 264 (87.5) | 72 (82.8) | 295 (86.8) | 97 (83.7) | 270 (86.9) | ||||
Oral ulcera | + | 9 (16.6) | 55 (22.3) | 0.463 | 9 (21.9) | 55 (21.2) | 1.000 | 17 (26.5) | 47 (19.1) | 0.301 |
– | 45 (83.3) | 191 (77.6) | 32 (78.1) | 204 (78.8) | 47 (73.5) | 198 (80.9) | ||||