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Table 4 Low gene copy number (GCN) for total C4, C4A and C4B genes is associated with systemic lupus erythematosus (SLE)

From: Impact of C4, C4A and C4B gene copy number variation in the susceptibility, phenotype and progression of systemic lupus erythematosus

  Total C4 GCN category C4A GCN category C4B GCN category
< 4 ≥4 < 2 ≥2 < 2 ≥2
Controls (n = 301) 41 (13.6)* 260 (86.3) 20 (6.6) 281 (93.3) 61 (20.2) 240 (79.7)
SLE (n = 427) 125 (29.2) 302 (70.7) 87 (20.3) 340 (79.6) 116 (27.1) 311 (72.8)
p-value** < 0.001 < 0.001 0.033
OR (95% CI) 2.62 (1.77–3.87) 3.59 (2.15–5.99) 1.46 (1.03–2.08)
  1. * Numbers within brackets are percentage; ** Fisher’s exact test