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Table 4 Low gene copy number (GCN) for total C4, C4A and C4B genes is associated with systemic lupus erythematosus (SLE)

From: Impact of C4, C4A and C4B gene copy number variation in the susceptibility, phenotype and progression of systemic lupus erythematosus

 

Total C4 GCN category

C4A GCN category

C4B GCN category

< 4

≥4

< 2

≥2

< 2

≥2

Controls (n = 301)

41 (13.6)*

260 (86.3)

20 (6.6)

281 (93.3)

61 (20.2)

240 (79.7)

SLE (n = 427)

125 (29.2)

302 (70.7)

87 (20.3)

340 (79.6)

116 (27.1)

311 (72.8)

p-value**

< 0.001

< 0.001

0.033

OR (95% CI)

2.62 (1.77–3.87)

3.59 (2.15–5.99)

1.46 (1.03–2.08)

  1. * Numbers within brackets are percentage; ** Fisher’s exact test
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Advances in Rheumatology

ISSN: 2523-3106