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Table 3 Distribution of SLE and controls according to the gene copy number for total C4, C4A and C4B

From: Impact of C4, C4A and C4B gene copy number variation in the susceptibility, phenotype and progression of systemic lupus erythematosus

GCN C4 n (%) C4A n (%) C4B n (%)
Controls (n = 301) SLE (n = 427) p-value Controls (n = 301) SLE (n = 427) p-value Controls (n = 301) SLE (n = 427) p-value
0 0 (0) 0 (0) 1.00 1 (0.3) 9 (2.1) 0.053 5 (1.7) 14 (3.3) 0.239
1 0 (0) 1 (0.2) 1.00 19 (6.3) 78 (18.3) < 0.001 56 (18.6) 102 (23.9) 0.100
2 3 (1.0) 30 (7.0) < 0.001 209 (69.4) 249 (58.3) < 0.01 198 (65.8) 245 (57.4) 0.025
3 38 (12.6) 94 (22.0) < 0.01 57 (18.9) 69 (16.2) 0.371 36 (12.0) 56 (13.1) 0.734
4 190 (63.1) 224 (52.5) < 0.01 9 (3.0) 16 (3.7) 0.682 3 (1.0) 9 (2.1) 0.377
5 53 (17.6) 60 (14.1) 0.213 5 (1.7) 4 (0.9) 0.500 3 (1.0) 1 (0.2) 0.312
6 11 (3.7) 11 (2.6) 0.510 1 (0.3) 2 (0.5) 1.00    
7 4 (1.3) 6 (1.4) 1.00       
8 2 (0.7) 1 (0.2) 0.573       
  1. Fisher’s exact test