Dot-plot and histograms of lymphocytes separated by size and granularity (a and b) and the subpopulation of CD4 T cells (c and d) which express CD69, highlighted in the central quadrant, from a control (e and f) and a SLE induced animal (g e h). i: Expression of CD69 in CD4+ T cells in blood, spleen and PL of SLE induced animals (dark bars) and controls (light bars) on D90 and D120. Results expressed as mean ± SD. Mann-Whitney Test, *p=0.005. Scatter plot showing results of Pearson’s correlation analysis. Positive correlation between CD4+CD69+ T cells in PL of SLE-induced animals and (j) IL-2 (r=0.606, p<0.0001) and (k) IFN-γ (r=0.604, p=0.0001). *p=0.005.