Skip to main content
Fig. 2 | Advances in Rheumatology

Fig. 2

From: CD4+CD69+ T cells and CD4+CD25+FoxP3+ Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice

Fig. 2

Panoramic histological cut of spleen from control group animal and SLE induced animal. a) Spleen of control animal showing preserved capsule of dense connective tissue and septa dividing the interior tissue of the organ in lobules interconnected. b) splenic parenchyma consisting of red pulp rich in sinusoids capillaries and splenic tissue cords constituted by macrophages, plasma cells, reticular cells and blood cells within the standards of normality. It is observed still rare megakaryocytes cells. The white pulp is constituted by lymphatic nodes characterized by lymphocyte cells arranged around the arterial branches with preserved architecture. c) Spleen of a SLE induced animal revealing rarefaction of white pulp characterized by loss of architecture of lymphatic nodes (d, arrow) which is characterized by replacement of lymphatic nodes by deposits of greasy material distributed diffusely (tips of arrows). These alterations are intensified on T120 (e and f, tips of arrows) Original magnification X2 and X40.

Back to article page

Advances in Rheumatology

ISSN: 2523-3106