TY - JOUR AU - Peixoto, Tatiana Vasconcelos AU - Carrasco, Solange AU - Botte, Domingos Alexandre Ciccone AU - Catanozi, Sergio AU - Parra, Edwin Roger AU - Lima, Thaís Martins AU - Ugriumov, Natasha AU - Soriano, Francisco Garcia AU - de Mello, Suzana Beatriz Verissímo AU - Rodrigues, Caio Manzano AU - Goldenstein-Schainberg, Cláudia PY - 2019 DA - 2019/07/24 TI - CD4+CD69+ T cells and CD4+CD25+FoxP3+ Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice JO - Advances in Rheumatology SP - 30 VL - 59 IS - 1 AB - Adaptive immune cells, including CD4+CD69+ and CD4+CD25+FoxP3+ regulatory T (Treg) cells, are important for maintaining immunological tolerance. In human systemic lupus erythematosus (SLE), CD4+CD25+FoxP3+ Treg cells are reduced, whereas CD69 expression is increased, resulting in a homeostatic immune imbalance that may intensify autoreactive T cell activity. To analyze the mechanisms implicated in autotolerance failure, we evaluated CD4+CD69+ and CD4+CD25+FoxP3+ T cells and interleukin profiles in a pristane-induced SLE experimental model. SN - 2523-3106 UR - https://doi.org/10.1186/s42358-019-0072-x DO - 10.1186/s42358-019-0072-x ID - Peixoto2019 ER -