Table 1 Demographic data and clinical manifestations of the 67 patients with nephritis due to Henoch-Schönlein Purpura
Demographic and clinical data | Total number N = 67(%) | Patients off immunosuppressants N = 54(%) | Patients on immunosuppressants N = 13 (%) | p-value |
|---|---|---|---|---|
Female | 42 (62.6) | 36 (66) | 6 (46.1) | 0.680* |
Age at onset (mean age in years, min. - max.) | 7 (2–15) | 6.5 (2–15) | 8.0 (4–11) | 0.453*** |
Time of follow up (median in years, min-max.) | 4.0 (1–12) | 2 (1–12) | 4(1–9) | < 0.001*** |
Cutaneous necrosis or ulcerations | 6 (8.9) | 5 (9.2) | 1 (7.6) | 0.190** |
Intestinal Impairment | 47 (70.1) | 37 (68.5) | 10 (76.9) | 1.0** |
Intestinal bleeding | 15 (22.3) | 13 (24) | 2 (15.3) | 0.719** |
Arthritis | 41 (61.1) | 32 (59.2) | 9 (69.2) | 0.604* |
Initial renal impairment | 53 (79.1) | 40 (74) | 13 (100) | |
Microscopic hematuria | 45 (67.1) | 41 (75.9) | 4 (30.7) | 0.349** |
Macroscopic hematuria | 14 (20.8) | 7 (12.9) | 7 (5.,8) | 0.277** |
Isolated hematuria | 22 (32.8) | 22 (40) | 0 | 0.003** |
Isolated proteinuria | 6 (8.9) | 5 (9.2) | 1 (7.6) | 0.790** |
Non-nephrotic proteinuria | 33 (49.2) | 29 (5.7) | 4 (30.7) | 0.206* |
Nephrotic proteinuria | 10 (14.9) | 1 (1.8) | 9 (69.2) | 0.000** |
Nephritic syndrome | 6 (8.9) | 1 (1.8) | 5 (38) | 0.001** |
Kidney biopsy | 20 (29.8) | 10 (18.5) | 10 (76.9) | 0,0002** |
Reduction of renal function | 1 (1.5) | 0 | 1 (7.6) | 0.209** |
Systemic Arterial Hypertension | 12 (17.9) | 5 (9.2) | 7 (53.8) | 0.001** |
Scrotal involvement | 0 | 0 | 0 | 0 |
Pulmonary involvement | 0 | 0 | 0 | 0 |
Neuropsychiatric involvement | 0 | 0 | 0 | 0 |
Pulse therapy with IVglucocorticoid | 16 (23.8) | 7 (12.9) | 9 (69.2) | 0.000** |
Oral glucocorticoid | 40 (59.7) | 27 (39.7) | 13 (100) | 0.045* |