TY - JOUR AU - Ugolini-Lopes, Michelle R. AU - Mantovani, Elenice AU - Bonoldi, Virgínia Lucia N. AU - de Medeiros Ribeiro, Ana Cristina AU - Bonfá, Eloisa AU - Yoshinari, Natalino AU - Andrade, Danieli PY - 2019 DA - 2019/05/14 TI - Anti-collagen type v: a marker of early systemic sclerosis? JO - Advances in Rheumatology SP - 19 VL - 59 IS - 1 AB - To evaluate the frequency of anti-collagen type V in humans with early systemic sclerosis (SSc) compared to defined SSc patients and healthy controls, since collagen type V was shown to be overexpressed in early SSc patients’ skin and there is no data concerning the presence of this antibody in early stages of human SSc. Experimental studies showed that animal models immunized with collagen type V developed a disease similar to human systemic sclerosis (SSc), with antibodies production, mainly in early stages post-immunization. SN - 2523-3106 UR - https://doi.org/10.1186/s42358-019-0063-y DO - 10.1186/s42358-019-0063-y ID - Ugolini-Lopes2019 ER -