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Table 3 Comparison of patients with and without atherosclerotic plaques

From: Methotrexate use, not interleukin 33, is associated with lower carotid intima-media thickness in patients with rheumatoid arthritis

Variable

Plaques absent

(n = 78)

Plaques present

(n = 24)

p-value

Age (years - mean ± SD)

54.2 ± 9.8

59.9 ± 9.7

0.014a

Disease length (years - mean ± SD)

16.3 ± 9.7

21.9 ± 8

0.011a

Postmenopausal (n (%)): No

Yes

21 (91.3)

50 (70.4)

2 (8.7)

21 (29.6)

0.043b

LDL within goal (Ref. 65) (n (%)) No

Yes

56 (70)

22 (100)

24 (30)

0 (0)

0.003b

Global CVR score (median (IQR))

6.3 (2.9–11.6)

8.7 (6.2–11.8)

0.048c

IMT (mm - median (IQR))

0.6 (0.6–0.8)

0.8 (0.7–0.9)

0.001c

IL-33 (n (%))d: positive

negative

52 (76.5)

26 (76.5)

16 (23.5)

8 (23.5)

1b

IL-33 (pg/mL - median (IQR))e

33.1 (0–78.7)

12.1 (0–85.8)

0.856c

IL-33 (pg/mL - median (IQR))f

69.1 (33.1–124.3)

70.6 (12.1–90.1)

0.745c

sST2 (pg/mL - median (IQR))g

461.7 (316.6–651)

485.9 (372.9–649)

0.675c

IL-33/sST2 (median (IQR))h

0.1 (0–0.3)

0.1 (0–0.3)

0.965c

  1. at-test; bchi-square; cMann-Whitney test
  2. SD standard deviation, NPJ number of painful joints upon physical examination, IQR interquartile range, SAH systemic arterial hypertension, CVR cardiovascular risk, NSAIDs nonsteroidal anti-inflammatory drugs; and IMT intima-media thickness
  3. dIL-33 positive: serum IL-33 ≥ 23.4 pg/mL; and IL-33 negative: serum IL-33 < 23.4 pg/mL
  4. elevels below the limit of detection were considered as zero
  5. fonly considering the 68 participants with levels above the limit of detection
  6. gdata from the 101 participants with detectable levels
  7. hIL-33-to-sST2 ratio