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Table 4 Minimal period recommended between therapy withdrawal and yellow fever vaccination in patients with CIMID

From: Brazilian recommendations on the safety and effectiveness of the yellow fever vaccination in patients with chronic immune-mediated inflammatory diseases

Drug

Interval between withdrawal and YFV

Prednisone > 20 mg/day or pulse methylprednisolone

At least one month

Hydroxychloroquine, sulfasalazine, acitretin, methotrexate ≤20 mg/week, or leflunomide 20 mg/daya

Consider vaccination without interval

Methotrexate > 20 mg/week

At least 1 month

Azathioprine, mycophenolate mofetil or sodic, cyclosporine, tacrolimus, or cyclophosphamide

At least 3 months

Tofacitinib

At least 2 weeks

Anti-cytokines and co-stimulation inhibitor

4–5 half-livesb

B-lymphocyte depletors

6–12 months

  1. the medical criterion to carry out the drug elimination protocol before indicating the vaccine bbased on pharmacological half-life, except for B-lymphocyte depletors