| SLE-nPAH n = 44 | SLE-PAH n = 21 | P-value |
---|---|---|---|
Age at SLE diagnosis (years) | 31.2 ± 12.3 | 28.8 ± 10.2 | 0.411 |
Age at PAH diagnosis (years) | – | 35.5 ± 11.8 | – |
Duration of disease at recruitment (years) | 5.6 ± 3.2 | 6.7 ± 6.4 | 0.437 |
Female sex, n (%) | 42 (95.5) | 20 (95.2) | 0.969 |
Smoker, n (%) | 0 (0) | 1 (4.8) | 0.145 |
Ex-smoker, n (%) | 4 (9.1) | 1 (4.8) | 0.295 |
ACR SLE criteria, n (%) | |||
 Malar rash | 34 (77.3) | 13 (65) | 0.303 |
 Photosensitivity | 35 (79.5) | 11 (55) | 0.043 |
 Discoid rash | 3 (6.8) | 0 (0) | 0.232 |
 Oral ulcers | 7 (15.9) | 4 (20) | 0. 688 |
 Arthritis | 41 (93.2) | 14 (70) | 0.013 |
 Serositis | 2 (40%) | 12 (60) | 0.112 |
 Hematologic involvement | 27 (61.4) | 14 (70) | 0.504 |
 Renal involvement | 18 (40.9) | 7 (35) | 0.635 |
 Neuropsychiatric involvement | 8 (18.2) | 4 (20) | 0.863 |
 ANA | 44(100) | 19 (90.4) | 0.189 |
 Anti-dsDNA, anti-Sm, or antiphospholipid | 25 (56.8) | 11 (57.9) | 0.937 |
Raynaud’s phenomenon, n (%) | 25 (56.8) | 17 (81) | 0.057 |
Livedo reticularis, n (%) | 0 (0) | 1 (4.8) | 0.145 |
Arterial thrombosis, n (%) | 0 (0) | 1 (4.8) | 0.145 |
Venous thrombosis, n (%) | 7 (15.9) | 5 (23.8) | 0.443 |
SLEDAI | 1.91 ± 3.16 | 2.56 ± 3.79 | 0.559 |
Pregnancy, n (%) | 26 (59.1) | 14 (66.7) | 0.557 |
Miscarriage, n (%) | 4 (9.1) | 6 (28.6) | 0.042 |
Anti-SM, n (%) | 10 (22.7) | 4 (23.5) | 0.947 |
Anti-RNP, n (%) | 19 (43.2) | 11 (64.7) | 0.132 |
Anti-Ro, n (%) | 11 (25) | 5 (29.4) | 0.725 |
Anti-La, n (%) | 5 (11.4) | 2 (11.8) | 0.965 |
Positive anti- aCL IgM, n (%) | 3 (7) | 2 (11.1) | 0.591 |
Positive anti- aCL IgG, n (%) | 7 (16.3) | 3 (16.7) | 0.970 |
Positive anti-dsDNA, n (%) | 15 (34.1) | 3 (17.6) | 0.207 |
C2 (mg/dL) | 91.4 ± 25.7 | 86.9 ± 29.8 | 0.690 |
CH100 (mg/dL) | 91.5 ± 24.8 | 89.4 ± 30.2 | 0.957 |
Hemoglobin (g/dL) | 12.5 ± 1.3 | 13.2 ± 1.5 | 0.138 |
Leukocytes (/mm3) | 6.317 ± 3.120 | 6.149 ± 3.766 | 0.977 |
Lymphocytes (/mm3) | 1.643 ± 899 | 1.477 ± 675 | 0.617 |
Platelets (/mm3) | 251.295 ± 101.691 | 197.500 ± 68.534 | 0.028 |
Creatinine (mg/dL) | 0.73 ± 0.23 | 0.86 ± 0.36 | 0.077 |
CRP (mg/dL) | 9.02 ± 14.3 | 12.10 ± 37.32 | 0.314 |
24-h urine protein (mg/kg/24 h) | 0.36 ± 0.52 | 0.26 ± 0.25 | 0.785 |