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Table 2 Demographic data, clinical manifestations and treatments in patients with scrotal involvement at first episode compared to those without this condition in 149 IgA vasculitis patients

From: Characterization of scrotal involvement in children and adolescents with IgA vasculitis

Variables at diagnosis, n (%) With scrotal involvement
(n = 27)
Without scrotal involvement
(n = 122)
Demographic data
 Age at diagnosis, years 4.0 (2.0–12.0) 6.0 (1.3–13.0)
 Body mass index, kg/m2, n = 139 16.4 (13.2–20.3) 16 (12.5–32.7)
Clinical/laboratorial involvements
 Persistent purpura/petechiae, n = 146 6/27 (22) 25/119 (21)
 Recurrent purpura/petechiae 7 (26) 20 (16)
 Purpura/petechiae duration, days, n = 140 18.5 (5–60) 14 (1–120)
 Arthritis/arthralgia 21 (78) 95 (77)
 Recurrent arthritis/arthralgia 1 (4) 6 (5)
 Arthritis/arthralgia duration, days, n = 100 4 (2–13) 6 (1–113)
 Abdominal pain 20 (74) 73 (59)
 Recurrent abdominal pain, n = 149 3/26 (12) 16/123 (13)
 Severe abdominal pain, n = 92 7/20 (35) 26/72 (36)
 Abdominal pain duration, days, n = 83 4.5 (1–40) 5 (1–60)
 Gastrointestinal bleeding, n = 149 6/27 (22) 23/122 (19)
 Bowel intussusception 0 (0) 1 (0.8)
 Nephritis, n = 147 10/27 (37) 56/120 (47)
 Arterial hypertension, n = 122 4/22 (18) 16/100 (16)
 Nephrotic syndrome, n = 147 0/26 (0) 3/121 (3)
 Acute kidney injury, n = 145 0/27 (0) 2/118 (2)
 Leukocyturia, n = 146 0/27 (0) 14/119 (12)
 Urinary casts, n = 146 2/27 (7) 13/119 (11)
 Hematuria, n = 146 7/27 (26) 39/119 (33)
 Proteinuria, n = 108 5/17 (29) 34/91 (37)
 Neuropsychiatric involvement 0 (0) 1 (1)
 Increased serum IgA, n = 76 2/11 (18) 37/65 (57)*
Treatments
 Prednisone 25 (93) 60 (49)*
 Intravenous metilprednisolone 0 (0) 1 (1)
 Prednisone dose, mg/kg/day, n = 72 2 (0.5–2) 1 (0.2–30)
 Glucorticosteroid duration, days, n = 76 47.5 (7–140) 37.5 (1–240)
 Ranitidine, n = 149 17/27 (63) 37/122 (30)*
 Ranitidine duration, days, n = 57 35 (2–90) 60 (5–425)
 Immunosuppressive agents 0 (0) 0 (0)
 IVIG 1 (4) 1 (1)
  1. Results are presented as median (minimum value - maximum value) or n (%), increased serum IgA (> 255 mg/dL), IVIG - intravenous immunoglobulin, *p value < 0.05 and the other comparisons between two groups were non-significant