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Table 4 Current laboratory tests and drug therapy of childhood-onset systemic lupus erythematosus (cSLE) according to the presence of diffuse alveolar hemorrhage (DAH)

From: Diffuse alveolar hemorrhage in childhood-onset systemic lupus erythematosus: a severe disease flare with serious outcome

Variables With DAH (at diagnosis)
(n = 19)
Without DAH (at last visit)
(n = 76)
P
Current laboratory exams
 Autoimmune hemolytic anemia 5 (26) 8 (10) 0.127
 Thrombocytopenia, < 150,000/mm3, n = 93 10 (52) 9/74 (12) < 0.0001*
 Anti-ds-DNA, n = 75 8/13 (61) 30/62 (48) 0.544
Drug therapy
 Prednisone current dose, mg/Kg, n = 82 1.4 (0.3–2) 0.5 (0.03–3) < 0.0001*
 Intravenous methylprednisolone 18 (95) 12 (15) < 0.0001*
 Antimalarial drugs 14 (74) 41 (54) 0.193
 Azathioprine 2 (10) 16 (21) 0.513
 Mycophenolate mofetil 1 (5) 5 (6) 1.000
 Intravenous cyclophosphamide 9 (47) 6 (8) < 0.0001*
  1. *P-value according to Bonferroni correction for multiple comparisons (p < 0.0022). Results are presented in n (%) and median (range), anti-ds-DNA – anti-double-stranded DNA antibodies