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Table 3 Demographic data, clinical manifestations and disease activity score in childhood-onset systemic lupus erythematosus (cSLE) patients according to the presence of diffuse alveolar hemorrhage (DAH)

From: Diffuse alveolar hemorrhage in childhood-onset systemic lupus erythematosus: a severe disease flare with serious outcome

Variables With DAH (at diagnosis)
(n = 19)
Without DAH (at last visit)
(n = 76)
P
Demographic data
 Female gender 14 (74) 66 (87) 0.172
 Disease duration, months 3 (1–151) 4 (1–151) 0.335
 Current age, years 13 (9–18) 13 (3–23) 0.889
Current clinical manifestations
 Constitutional 14 (74) 8 (10) < 0.0001*
 Mucocutaneous 9 (47) 31 (41) 0.614
 Musculoskeletal 5 (26) 8 (10) 0.127
 Serositis 12 (63) 5 (6) < 0.0001*
 Neuropsychiatric 4 (21) 11 (14) 0.491
 Nephritis 16 (84) 42 (55) 0.033
 Current autoimmune thrombosis (APS), n = 90 0/16 (0) 1/74 (1) 1.000
Sepsis 10 (53) 7 (9) < 0.0001*
Macrophage activation syndrome 2 (10) 2 (3) 0.113
Death, n = 94 9 (47) 15/75 (20) 0.020
Current disease activity
 SLEDAI-2 K, n = 82 18 (5–40) 6 (0–44) < 0.0001*
  1. *P-value according to Bonferroni correction for multiple comparisons (p < 0.0022). Results are presented in n (%) and median (range), APS Antiphospholipid syndrome, SLEDAI-2 K Systemic Lupus Erythematosus Disease Activity Index 2000