Table 4 Studies investigating the association of adiponectin and rheumatoid arthritis in humans
Authors | Study design | Subjects | Results/outcomes |
|---|---|---|---|
Rho et al. (2010) [19] | Cross-sectional study evaluating correlation between HOMA-IR and serum adipokine levels. | 169 RA patients | No correlation between adiponectin and insulin resistance. |
Alkady et al. (2011) [52] | Case-control study evaluating correlation between serum and synovial liquid adipokines and disease activity. | 70 RA patients 30 controls | Positive correlation between serum and synovial adiponectin levels and disease activity. |
Yoshino et al. (2011) [21] | Case-control study evaluating correlation between inflammation markers and serum adipokine levels. | 141 RA patients 146 controls | No correlation between serum adiponectin levels and CRP. |
Giles et al. (2011) [67] | Prospective study evaluating association of serum adipokine levels with progression of radiographic joint damage in patients with rheumatoid arthritis. | 152 RA patients | Positive correlation between serum adiponectin levels and erosive joint destruction. |
Klein-Wieringa et al. (2011) [68] | Cohort study evaluating baseline adipokine levels to predict radiographic progression of RA over a period of 4 years. | 253 RA patients | Positive correlation between serum levels of adiponectin and radiographic progression of 4RA. |
Meyer et al. (2013) [56] | Cohort study evaluating serum adipokines levels and radiographic progression of RA. | 632 RA patients at early stage of disease and 159 with unspecific arthritis | Positive association between serum adiponectin levels and radiographic progression of RA at early stage. |
Bustos Rivera-Bahena et al. (2015) [24] | Cross-sectional study evaluating correlation between adipokines levels and disease activity. | 121 RA patients | No correlation between serum adiponectin and clinical activity of RA, but negative correlation with TNFα and positive correlation with IL-1β. |
Chennareddy et al. (2016) [70] | Cross-sectional study evaluating the serum concentrations of adiponectin and its impact on disease activity and radiographic joint damage. | 43 RA patients 25 controls | Increased levels of serum adiponectin in RA, but no correlation with erosive and non-erosive disease, disease duration, BMI, waist-hip ratio and disease activity. |