Skip to main content

Table 4 Studies investigating the association of adiponectin and rheumatoid arthritis in humans

From: Adipokines in rheumatoid arthritis

Authors Study design Subjects Results/outcomes
Rho et al. (2010) [19] Cross-sectional study evaluating correlation between HOMA-IR and serum adipokine levels. 169 RA patients No correlation between adiponectin and insulin resistance.
Alkady et al. (2011) [52] Case-control study evaluating correlation between serum and synovial liquid adipokines and disease activity. 70 RA patients
30 controls
Positive correlation between serum and synovial adiponectin levels and disease activity.
Yoshino et al. (2011) [21] Case-control study evaluating correlation between inflammation markers and serum adipokine levels. 141 RA patients
146 controls
No correlation between serum adiponectin levels and CRP.
Giles et al. (2011) [67] Prospective study evaluating association of serum adipokine levels with progression of radiographic joint damage in patients with rheumatoid arthritis. 152 RA patients Positive correlation between serum adiponectin levels and erosive joint destruction.
Klein-Wieringa et al. (2011) [68] Cohort study evaluating baseline adipokine levels to predict radiographic progression of RA over a period of 4 years. 253 RA patients Positive correlation between serum levels of adiponectin and radiographic progression of 4RA.
Meyer et al. (2013) [56] Cohort study evaluating serum adipokines levels and radiographic progression of RA. 632 RA patients at early stage of disease and 159 with unspecific arthritis Positive association between serum adiponectin levels and radiographic progression of RA at early stage.
Bustos Rivera-Bahena et al. (2015) [24] Cross-sectional study evaluating correlation between adipokines levels and disease activity. 121 RA patients No correlation between serum adiponectin and clinical activity of RA, but negative correlation with TNFα and positive correlation with IL-1β.
Chennareddy et al. (2016) [70] Cross-sectional study evaluating the serum concentrations of adiponectin and its impact on disease activity and radiographic joint damage. 43 RA patients
25 controls
Increased levels of serum adiponectin in RA, but no correlation with erosive and non-erosive disease, disease duration, BMI, waist-hip ratio and disease activity.
  1. RA = rheumatoid arthritis; IR = insulin resistance; CRP = C-reactive protein; BMI = body mass index