Skip to main content

Table 3 Studies investigating the association of visfatin and rheumatoid arthritis in humans

From: Adipokines in rheumatoid arthritis

Authors Study design Subjects Results/outcomes
Rho et al. (2010) [19] Cross-sectional study evaluating correlation between HOMA-IR and serum adipokine levels. 169 RA patients No correlation between visfatin levels and IR
Alkady et al. (2011) [52] Case-control study evaluating correlation between serum and synovial liquid adipokines and disease activity. 70 RA patients
30 controls
Positive correlation between serum visfatin levels and disease activity.
Khalifa et al. (2013) [53] Case-control study evaluating correlation between serum visfatin and inflammation markers. 60 RA patients
20 controls
Positive correlation between visfatin levels and IL-6, CRP, ERS, TNF-α and DAS-28 in RA.
El-Hini et al. (2013) [54] Case-control study evaluating metabolic disorder and its association with clinical characteristics of RA patients. 40 RA patients
40 controls
Positive correlations between serum visfatin levels and IR, cholesterol, triglycerides and LDL-C.
Meyer et al. (2013) [56] Cohort study evaluating serum adipokine levels and radiographic progression of RA. 632 RA patients at early stage of disease and 159 with unspecific arthritis No correlation between visfatin levels and progression of RA.
Sglunda et al. (2014) [55] Prospective study evaluating visfatin level and its relationship with disease activity and serum lipids. 40 patients with early, treatment-naïve RA
30 controls
Correlation between visfatin levels and disease activity and reduced levels after treatment.
Mirfeizi et al. (2014) [30] Cross-sectional study evaluating correlation between serum adipokines levels and radiographic joint damage. 54 RA patients (29 with erosion and 25 without erosion) The levels of visfatin were higher in patients with radiographic joint damage and dependent on the duration of the disease.
  1. RA = rheumatoid arthritis; IR = insulin resistance; MetS = metabolic syndrome; IL-6 = interleukin-6; CRP = C-reactive protein; ESR = erythrocyte sedimentation rate; DAS28 = Disease Activity Score-28; TNF-α = tumor necrosis factor α; LDL-C = low-density lipoprotein cholesterol