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Table 2 Studies investigating the association of resistin and rheumatoid arthritis in humans

From: Adipokines in rheumatoid arthritis

Authors Study design Subjects Results/outcomes
Kassem et al. (2010) [36] Case-control study evaluating correlation between serum and synovial resistin and inflammation markers, disease activity and radiographic joint damage. 30 RA patients
15 healthy controls
Significant correlation between serum resistin levels and CRP, ESR, rheumatoid factor and disease activity. Also considered a good prognostic marker of RA.
Rho et al. (2010) [19] Cross-sectional study evaluating correlation between HOMA-IR and serum adipokine levels. 169 RA patients No significant correlation between serum resistin and insulin resistance.
Al-Kady et al. (2010) [39] Case-control study evaluating correlation between serum and synovial liquid adipokines and disease activity. 70 RA patients
30 controls
No differences between groups in serum resistin, but it was observed synovial liquid resistin levels significantly higher in patients with active disease.
Yoshino et al. (2011) [21] Case-control study evaluating correlation between inflammation markers and serum adipokines levels. 141 RA patients
146 controls
No differences in serum resistin between groups, but in RA patients it was positively associated with CRP levels.
Kontunen et al. (2011) [22] Cross-sectional study evaluating correlation between serum adipokine levels and markers of inflammation and MetS in RA. 54 RA patients, 20 with MetS Increased levels of resistin were associated with RA irrespective of the presence of MetS.
Fadda et al. (2013) [37] Case-control study comparing serum and synovial liquid resistin in patients with RA and osteoarthritis. 25 RA patients
25 osteoarthritis patients
Significant correlation between synovial liquid resistin and rheumatoid factor and ACPA, indicating a bad prognosis of disease.
Kang et al. (2013) [23] Cross-sectional study evaluating correlation between adipokines levels, inflammation markers, insulin resistance and atherosclerosis. 192 RA patients Significant correlation between serum resistin and inflammation markers ESR and CRP and disease duration.
Hammad et al. (2014) [40] Case-control study comparing serum resistin in RA patients and a control group and its association to disease activity. 30 RA patients
30 controls
No correlation between serum resistin levels and clinical and laboratorial markers of disease activity.
Bustos Rivera-Bahena et al. (2015) [24] Cross-sectional study evaluating correlation between adipokines levels and disease activity. 121 RA patients Positive correlation between resistin levels and disease activity.
Huang et al. (2015) [38] Meta-analysis evaluating correlation between serum resistin levels and RA. 8 studies with RA:
620 RA patients
460 controls
Serum resistin levels were significantly higher in patients with RA.
  1. RA = rheumatoid arthritis; CRP = C-reactive protein; TNF-α = tumor necrosis factor-α; ESR = erythrocyte sedimentation rate; ACPA = anti-citrullinated protein antibody; HOMA-IR = homeostatic model assessment-insulin resistance; Metabolic Syndrome = MetS