Table 2 Studies investigating the association of resistin and rheumatoid arthritis in humans
Authors | Study design | Subjects | Results/outcomes |
|---|---|---|---|
Kassem et al. (2010) [36] | Case-control study evaluating correlation between serum and synovial resistin and inflammation markers, disease activity and radiographic joint damage. | 30 RA patients 15 healthy controls | Significant correlation between serum resistin levels and CRP, ESR, rheumatoid factor and disease activity. Also considered a good prognostic marker of RA. |
Rho et al. (2010) [19] | Cross-sectional study evaluating correlation between HOMA-IR and serum adipokine levels. | 169 RA patients | No significant correlation between serum resistin and insulin resistance. |
Al-Kady et al. (2010) [39] | Case-control study evaluating correlation between serum and synovial liquid adipokines and disease activity. | 70 RA patients 30 controls | No differences between groups in serum resistin, but it was observed synovial liquid resistin levels significantly higher in patients with active disease. |
Yoshino et al. (2011) [21] | Case-control study evaluating correlation between inflammation markers and serum adipokines levels. | 141 RA patients 146 controls | No differences in serum resistin between groups, but in RA patients it was positively associated with CRP levels. |
Kontunen et al. (2011) [22] | Cross-sectional study evaluating correlation between serum adipokine levels and markers of inflammation and MetS in RA. | 54 RA patients, 20 with MetS | Increased levels of resistin were associated with RA irrespective of the presence of MetS. |
Fadda et al. (2013) [37] | Case-control study comparing serum and synovial liquid resistin in patients with RA and osteoarthritis. | 25 RA patients 25 osteoarthritis patients | Significant correlation between synovial liquid resistin and rheumatoid factor and ACPA, indicating a bad prognosis of disease. |
Kang et al. (2013) [23] | Cross-sectional study evaluating correlation between adipokines levels, inflammation markers, insulin resistance and atherosclerosis. | 192 RA patients | Significant correlation between serum resistin and inflammation markers ESR and CRP and disease duration. |
Hammad et al. (2014) [40] | Case-control study comparing serum resistin in RA patients and a control group and its association to disease activity. | 30 RA patients 30 controls | No correlation between serum resistin levels and clinical and laboratorial markers of disease activity. |
Bustos Rivera-Bahena et al. (2015) [24] | Cross-sectional study evaluating correlation between adipokines levels and disease activity. | 121 RA patients | Positive correlation between resistin levels and disease activity. |
Huang et al. (2015) [38] | Meta-analysis evaluating correlation between serum resistin levels and RA. | 8 studies with RA: 620 RA patients 460 controls | Serum resistin levels were significantly higher in patients with RA. |