From: Relevance of serum angiogenic cytokines in adult patients with dermatomyositis
Parameters | DM (n = 48) | Control (n = 48) | P value |
---|---|---|---|
Age (years) | 33.3 ± 7.6 | 35.8 ± 8.2 | 1.000 |
White ethnicity | 36 (75.0) | 32 (66.7) | 0.501 |
Female gender | 36 (75.0) | 36 (75.0) | 1.000 |
Age at disease onset (years) | 30.9 ± 7.4 | – | – |
Duration: diagnosis - symptoms (months) | 5.0 (2.3–8.5) | – | – |
Disease duration (years) | 1 (0–4) | – | – |
Clinical cumulative manifestations | |||
Articular involvement | 14 (29.2) | – | – |
Pulmonary involvement | 17 (35.4) | – | – |
Cutaneous involvement | 48 (100.0) | – | – |
Gottron’s papules | 47 (97.9) | – | – |
Heliotrope rash | 40 (83.3) | – | – |
Facial rash | 30 (62.5) | – | – |
Raynaud’ phenomenon | 24 (50.0) | – | – |
“V-neck” sign | 15 (31.3) | – | – |
Ulcers | 10 (20.8) | – | – |
Vasculitis | 10 (20.8) | – | – |
“Shawl” sign | 8 (16.7) | – | – |
Calcinosis | 0 | – | – |
MMT-8 (0–80) | 78 (71–80) | ||
HAQ (0.00–3.00) | 0.36 (0.00–2.00) | – | – |
Patient VAS (0–10 mm) | 5 (1–6) | – | – |
Physician VAS (0–10 mm) | 4 (1–5) | – | – |
Creatine phosphokinase (U/L) | 200 (93–960) | 100 (81–161) | 0.002 |
Aldolase (U/L) | 5.9 (4.1–12.9) | 3.6 (3.1–4.3) | < 0.001 |
Lactic dehydrogenase (U/L) | 412 (347–597) | 323 (296–381) | < 0.001 |
Alanine aminotransferase (U/L) | 25 (16–60) | 17 (13–21) | < 0.001 |
Aspartate aminotransferase (U/L) | 25 (19–52) | 19 (16–22) | < 0.001 |
Prednisone | |||
Current use | 34 (70.8) | – | – |
Current dose (mg/day) | 20.0 (3.1–50.0) | – | – |
Cumulative dosea (mg) | 645 (90–2103) | – | – |
Cumulative doseb (g) | 15.5 (5.8–27.8) | – | – |
Immunosupressive/imunmodulatoryc | – | ||
None | 20 (41.7) | – | – |
One | 11 (22.9) | – | – |
Two | 17 (35.4) | – | – |