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Table 1 General features of patients with dermatomyositis and health individuals

From: Relevance of serum angiogenic cytokines in adult patients with dermatomyositis

Parameters

DM (n = 48)

Control (n = 48)

P value

Age (years)

33.3 ± 7.6

35.8 ± 8.2

1.000

White ethnicity

36 (75.0)

32 (66.7)

0.501

Female gender

36 (75.0)

36 (75.0)

1.000

Age at disease onset (years)

30.9 ± 7.4

Duration: diagnosis - symptoms (months)

5.0 (2.3–8.5)

Disease duration (years)

1 (0–4)

Clinical cumulative manifestations

 Articular involvement

14 (29.2)

 Pulmonary involvement

17 (35.4)

 Cutaneous involvement

48 (100.0)

  Gottron’s papules

47 (97.9)

  Heliotrope rash

40 (83.3)

  Facial rash

30 (62.5)

  Raynaud’ phenomenon

24 (50.0)

  “V-neck” sign

15 (31.3)

  Ulcers

10 (20.8)

  Vasculitis

10 (20.8)

  “Shawl” sign

8 (16.7)

  Calcinosis

0

MMT-8 (0–80)

78 (71–80)

  

HAQ (0.00–3.00)

0.36 (0.00–2.00)

Patient VAS (0–10 mm)

5 (1–6)

Physician VAS (0–10 mm)

4 (1–5)

Creatine phosphokinase (U/L)

200 (93–960)

100 (81–161)

0.002

Aldolase (U/L)

5.9 (4.1–12.9)

3.6 (3.1–4.3)

< 0.001

Lactic dehydrogenase (U/L)

412 (347–597)

323 (296–381)

< 0.001

Alanine aminotransferase (U/L)

25 (16–60)

17 (13–21)

< 0.001

Aspartate aminotransferase (U/L)

25 (19–52)

19 (16–22)

< 0.001

Prednisone

 Current use

34 (70.8)

 Current dose (mg/day)

20.0 (3.1–50.0)

 Cumulative dosea (mg)

645 (90–2103)

 Cumulative doseb (g)

15.5 (5.8–27.8)

Immunosupressive/imunmodulatoryc

  

 None

20 (41.7)

 One

11 (22.9)

 Two

17 (35.4)

  1. Results expressed as percentage (%), mean ± standard deviation, median (25th - 75th interquartile range)
  2. DM dermatomyositis, HAQ Health Assessment Questionnaire, MMT Muscle Manual Testing, VAS visual analogue score
  3. a Last 3 months; b since the begin of treatment; c imunossupressive / imunomodulatory: azathioprine (2–3 mg/kg/day), methotrexate (15–25 mg/week), cyclosporine (1.5–2.5 mg/kg/day), mycophenolate mofetil (2–3 g/day), rituximab (1 g, intravenous, at baseline and after one month - first cycle - and this schema was repeated after six months), cyclophosphamide (0.5–1.0 g/m2 body surface), leflunomide (20 mg/day) and/or intravenous human immunoglobulin (2 g/kg, daily, two consecutive days)