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Table 2 Demographic, clinical and laboratory features, treatment and outcome of SLE patients with HIV

From: Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients

Case Gender First DX Clinical features Autoantibodies SLE treatment ART CD4 at DXa Last CD4 Outcome
1 F SLE Discoid lupus, photosensitivity, oral ulcers and arthritis ANA and anti-Ro CS Yes 434 337 Good health condition, but loss of follow-up in the Rheumatology Clinic
2 F SLE Raynaud, arthritis and vasculitis ANA, anti-dsDNA, anti-Ro and anti-La CS Yes 572 205 Disseminated TB at 2015, follow-up in the Infectious Diseases Clinic
3 F SLE Arthritis, leucopenia, lymphopenia, alopecia, Raynaud and photosensitivity ANA HCQ Yes 424 1056 SLE in remission, HIV controlled
4 F SLE Discoid lupus, photosensitivity, nephritis, leucopenia and lymphopenia ANA HCQ Yes 149 524 HCV coinfection
SLE in remission and HIV controlled
5 F SLE Photosensitivity, oral ulcers, arthritis and nephritis ANA, anti-Ro and anti-La CS, AZA ➔ MMF and tacrolimus Yes 273 991 Pulmonary TB in 2008, kidney transplantation in 2011
6 F SLE Photosensitivity, serositis and arthritis ANA None Yes 172 391 HCV coinfection,
SLE in remission and HIV controlled
7 F SLE Alopecia, arthritis, nephritis, hemolytic anemia and hypergammaglobulinemia ANA, anti-dsDNA and anti-Ro HCQ, CYC
➔ AZA
Yes 321 165 Good initial response, poor adherence to treatment with posterior reactivation of nephritis and CD4 count drop
8 F HIV Hemolytic anemia, serositis, oral ulcers and arthritis ANA, anti-Sm and anti-RNP HCQ, MTX Yes NA 477 CMV Retinitis in 2006,
SLE in remission and HIV controlled
9 F HIV Hemolytic anemia and nephritis ANA and anti-dsDNA CS, HCQ
CYC ➔ AZA
Yes 235 252 Complete response to CYC, posterior poor adherence and loss of follow-up due to drug addiction
10 F SLE Hemolytic anemia, serositis, leucopenia, lymphopenia, oral ulcers, arthritis and nephritis ANA and anti-dsDNA HCQ Yes 203 323 SLE in remission and HIV controlled
11 F Both Alopecia, hemolytic anemia, nephritis, thrombocytopenia, leucopenia and lymphopenia ANA CS, HCQ
➔AZA
Yes 111 NA Both diagnosed in hospital stay, progressing to death from sepsis
  1. Abbreviations: ACL IgG anti-cardiolipin IgG, ACL IgM anti-cardiolipin IgM, ANA anti-nuclear antibody, ART active antiretroviral therapy, AZA azathioprine, CMV cytomegalovirus, CS corticosteroids, CYC cyclophosphamide, dsDNA anti-double-stranded DNA, DX diagnosis, F female, HCQ hydroxychloroquine, HIV human immunodeficiency virus, M male, MMF mycophenolate mofetil, MTX methotrexate, NA not available, SLE systemic lupus erythematosus, TB tuberculosis
  2. aCD4 cell count at diagnosis of HIV-infection: cells/mm3