Table 3 Allelic and genotype association testing results of rs1544410, rs7975232, and rs731236 in VDR for Mexican cases with osteoarthritis of the knee and controls
SNP | Cases (n = 107) n (%) | Controls (n = 114) n (%) | OR (CI 95%)a | p |
|---|---|---|---|---|
rs1544410 | ||||
Allele | ||||
A | 82 (38.0) | 97 (43.0) | 0.8 (0.6–1.2) | 0.4 |
G | 132 (62.0) | 131 (57.0) | 1.1 (0.8–1.8) | 0.4 |
Genotype | ||||
AA | 4 (3.7) | 9 (7.9) | 0.4 (0.1–1.5) | 0.2 |
GA | 74 (69.2) | 79 (69.3) | 0.9 (0.5–1.8) | 0.9 |
GG | 29 (27.1) | 26 (22.8) | 1.2 (0.6–2.3) | 0.5 |
rs7975232 | ||||
Allele | ||||
G | 112 (52.0) | 115 (50.0) | 1.1 (0.7–1.6) | 0.7 |
T | 102 (48.0) | 113 (50.0) | 0.9 (0.6–1.4) | 0.7 |
Genotype | ||||
GG | 17 (15.9) | 16 (14.0) | 1.1 (0.5–2.4) | 0.7 |
GT | 78 (72.9) | 83 (72.8) | 1.0 (0.5–1.8) | 0.9 |
TT | 12 (11.2) | 15 (13.2) | 0.8 (0.3–1.9) | 0.7 |
rs731236 | ||||
Allele | ||||
C | 35 (16.0) | 55 (24.0) | 0.6 (0.4–1.0) | 0.04 |
T | 179 (84.0) | 173 (76.0) | 1.6 (1.0–2.6) | 0.04 |
Genotype | ||||
CC | 3 (2.8) | 3 (2.6) | 1.1 (0.2–5.4) | 0.9 |
CT | 29 (27.1) | 49 (42.9) | 0.5 (0.3–0.9) | 0.01 |
TT | 75 (70.1) | 62 (54.4) | 1.9 (1.1–3.4) | 0.02 |